Hsp90 and the Fanconi Anemia Pathway: A Molecular Link Between Protein Quality Control and the DNA Damage Response
نویسندگان
چکیده
منابع مشابه
Hsp90 regulates the Fanconi anemia DNA damage response pathway.
Heat shock protein 90 (Hsp90) regulates diverse signaling pathways. Emerging evidence suggests that Hsp90 inhibitors, such as 17-allylamino-17-demethoxygeldanamycin (17-AAG), enhance DNA damage-induced cell death, suggesting that Hsp90 may regulate cellular responses to genotoxic stress. However, the underlying mechanisms are poorly understood. Here, we show that the Fanconi anemia (FA) pathway...
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Guest editorial: fanconi anemia and the DNA damage response.
Every cell in our body other than red blood cells has a genome, the stability of which is crucial for life. The DNA is precisely replicated during cell proliferation, and is stably maintained, even after terminal differentiation, as a repository of information that orchestrates the cell’s metabolism. Unfortunately, our world is full of potential threats to genomic stability. DNA may degrade spo...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2007
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.6.18.4653